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Scientists Identify New Immunotherapy Target for Pediatric Cancers

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Scientists in the U.S. and Canada have identified a key immunotherapy target for high-risk neuroblastoma and other childhood cancers, and developed an antibody-drug conjugate (ADC) targeting the cell surface co-receptor, glypican 2 (GLP2), which regressed tumors and prolonged life in a mouse model of neuroblastoma.

The researchers, led by John M. Maris, M.D., a pediatric oncologist at the Children’s Hospital of Philadelphia (CHOP), claim their work lays “firm groundwork” for the development of GPC2-directed immunotherapies against neuroblastoma, including ADCs but also potentially CAR T cell therapies.


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